Site Loader

1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

Author: Zulkisar Gugis
Country: Benin
Language: English (Spanish)
Genre: Environment
Published (Last): 23 September 2004
Pages: 226
PDF File Size: 6.98 Mb
ePub File Size: 1.41 Mb
ISBN: 115-2-88457-417-4
Downloads: 92113
Price: Free* [*Free Regsitration Required]
Uploader: Gogami

In healthy volunteers, a Cmax of 5. Interrupt telbivudine if peripheral neuropathy is suspected, and discontinue the drug if peripheral neuropathy is confirmed.

This may increase the chance of you getting an unwanted side effect. Variations in dosage exist among different interferon beta-1a products; these products are not equivalent.

Lamivudine; Tenofovir Disoproxil Fumarate: In contrast, none of the placebo recipients and Treatment with interferon beta-1a should be immediately stopped if jaundice or other clinical signs of liver dysfunction appear; the potential for rapid progression to liver failure exists if the drug is continued.

Subcutaneous and intramuscular administration have been observed to have non-equivalent pharmacokinetic and pharmacodynamic parameters after administration to healthy volunteers.

Pharmacokinetic data from patients with multiple sclerosis are not available. Contact MS ActiveSource for more information —— Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body, rash, itching or hives on the skin.

These include changes in thyroid function, liver function or blood counts. If self-injecting, rotate between thighs. The indicated dose is based on data suggesting that early initiation of interferon beta-1a therapy delays the onset of clinically definite MS in high-risk patients who have recently experienced a demyelinating event but do not aonex have clinical MS. This allows the temperature of the medicine to approach room temperature. Packagee Monitor for signs and symptoms of hepatic injury during coadministration of riluzole and interferon beta.


Do not inject if the solution is discoloured or cloudy or contains particles. The first injection should be performed under the supervision of an appropriately qualified health care professional. Place the device on a flat surface with the door open.

Avonex (interferon beta-1a) dose, indications, adverse effects, interactions from

aconex There is some evidence that interferon beta has greater in vitro antiproliferative effects against many solid tumor cell lines than interferon alpha. No cases of transmission of viral diseases or CJD have ever been identified for albumin.

Many people with MS learn to give themselves the injection or have it given by a carer. To prevent or slow the development of clinically definite MS in patients who have experienced a first clinical episode and have MRI features consistent with Vaonex. Self-injection needs to be taught and practised. Do not use if it is cloudy, discolored, or has particles. Avonex Pen should be injected into the upper, outer thigh.

Attach the needle by pressing it onto the syringe and turning it clockwise until it locks in aconex. Emtricitabine; Avoned Tenofovir alafenamide: Discontinuation of stavudine should be considered as medically appropriate. If he or she recommends that you take a medication to reduce symptoms of pain and inflammation, follow their advice carefully. If desired, the product may be removed from the refrigerator about 30 minutes before use.

Heating can damage this medicine.

Reduce the risk of relapse. This activity may contribute to the antiviral and antiproliferative effects of interferon beta. Nevirapine may cause liver damage in the context of hypersensitivity reactions or by direct toxic effects. Soreness, redness or bruising at the injection site. Autoimmune apckage of multiple target organs has been reported during interferon beta-1a therapy, including idiopathic thrombocytopenia, thyroid disease hyperthyroidism or hypothyroidismand rare cases of autoimmune hepatitis.

PDR Search

Subcutaneous administration of interferon beta-1a should not be substituted for intramuscular administration. The potential of additive effects from multiple drugs or other hepatotoxic agents has not been determined; however, caution is recommended if interferon beta-1a is given concurrently with any hepatotoxic agents.


Administration of Avonex pre-filled autoinjector: Furthermore, they state that there are lower rates of insedt mortality in coinfected patients taking HAART, even in those with end-stage liver disease, compared with patients not receiving HAART. If you forget to use it If it is less than 2 days before your next injection, skip the dose you missed and have your next injection when you are meant to.

Digital Security

Interferon beta is a Type I interferon. Firmly push the body of the pen down against the thigh to release the safety lock. If the goal dose is 44 mcg, in weeks 1 to 2 administer 8.

The regular schedule may then innsert continued, but do not give 2 injections within 2 days of each other. Abortifacient activity, menstrual irregularities, anovulation, and decreased serum progesterone levels have been observed in some animal studies, including studies in rhesus monkeys, during high dose use.

Tell your doctor or pharmacist if you notice anything that pckage making you feel unwell. Do not re-use needles, syringes, pre-filled syringes, titration devices, or autoinjectors. MS affects the brain and spinal cord. The 2-year, placebo-controlled PRISMS trial has shown that Rebif 22 mcg or 44 mcg subcutaneously 3 times weekly significantly reduces the number of relapses, delays disability progression, and reduces disease activity and burden as measured by MRI.

Glatiramer is a pacage alternative to interferon beta-1a in the treatment of multiple sclerosis; the high molecular weight of the drug would suggest significant transfer to breast milk would be unlikely but no specific information regarding its use in breast-feeding is available.